The MEE 2 and CI 1,14-20 have been widely applied in biomedical literature, especially in drug-combination studies for in vitro 1,9,17, in animals 15,18,19, and in clinical trials 15,20. The extension for MEE yields the combination index (CI) theorem of Chou-Talalay in 1983 12,13. It is shown that the “Median” is the common link and common reference point from the first-order to higher order dynamics and from single entity to the combination of multiple entities 10,11. The general validity is assured by the derivation via “mathematical induction and deduction” through over three hundred mechanism specific equations 2,6. This is why the median-effect equation and its principle and its median-effect plot is the Unified Theory that explicitly defined the interchangeable relationship between the dose and effect (or cause and consequence, matter and property, material and function), like two sides of the same coin, at the equilibrium dynamic state 1,7. Thus, a cup half-full is a cup half-empty, and the MEE described the dynamic relationship between fullness and emptiness. It is not surprising that half-affected (D m) is equivalent to half-saturated (K m), half occupied (K), half-ionized (pKa) and half-bound and half-free (Kd) in biochemistry and biophysics. the fraction “unaffected” in all cases 1,8,9. The rearrangement of MEE yields the mathematical form of the Michaelis-Menten, Hill, Henderson-Hasselbalch, and Scatchard equations and thus, these basic equations in biochemistry and biophysics are the special cases of MEE which described the quantitative relativity between the fraction “affected” vs.
COMPUSYN VS CALCUSYN FREE
I published the median-effect equation (MEE, the Median-Effect Theory) in the Journal of Theoretical Biology (59: 253-276) 2 in 1976 and its related studies 3-6 recently proposed the Median-based GPS-concept for bio-informatics in Nature Precedings (npre.2008.2064.2) 7 which is available free at. My proposition is that the “M” in the M-theory stands for “Median” with the evidences given below.
Speculations in public media include "Mother", “Master”, “Main”, “Magic”, “Miracle”, “Mystery”, “Muffin” and “Membrane”.
There is no telling what “M” in the M-theory means. This proposition is feasible due to the fact that sometimes different approaches (e.g., physical and biological models) can ultimately converge to the same conclusion and share the same implications.
COMPUSYN VS CALCUSYN PDF
If the M-theory is, indeed, universally true, I wonder if it is consistent with the “Unified Theory” of the median-effect principle of the mass-action law which is explicitly “derived” from the physico-chemical dynamics via mathematical induction and deduction (see Pharmacological Reviews 58: 621-681,2006 1 free PDF access at ). The experimental evidence for this theory remains to be seen but it has already elicited the debate on science and religion regarding who or what created the universe. Stephen Hawking’s “M-theory” (in The Grand Design, with Leonard Mlodinow, Bantam, New York, 2010) has been considered the fundamental law of Nature and our universe followed inevitably from this law.
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